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An important study that challenges the functional organization of the lytic synapse in CTLs.
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An early description of synapse formation in NK cells, long before the immunological synapse was defined as a biological concept (see also reference 55).
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This study is an important demonstration of the ability of NK cells to form lytic synapses with activated macrophages, which has clear implications for the pathogenesis of HLH.
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One of several important references (including references 23 and 24) that define the mechanisms by which the NK-cell inhibitory synapse can interfere with steps of NK-cell lytic-synapse formation.
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