Abstract
Interleukin-12p70 (IL-12p70) induces T-helper-1-cell responses and IL-23, a related cytokine, is the master switch in several T-cell-mediated inflammatory disorders. IL-27, another member of the IL-12 family, regulates innate and adaptive immune responses. Recently, distinct combinations of transcription factors have been shown to regulate the expression of the genes that encode these three cytokines. Toll-like receptor ligands, in association with other microbial products and endogenous mediators, tip the balance between the expression of IL-12 family members and thereby may control the outcome of T-cell-mediated inflammation. On this basis, we present a novel perspective on the pathogenesis and regulation of inflammatory disorders.
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Michel Goldman serves as a consultant for GlaxoSmithKline Biologicals (Rixensart, Belgium) and OM-Pharma (Meyrin, Switzerland).
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Goriely, S., Neurath, M. & Goldman, M. How microorganisms tip the balance between interleukin-12 family members. Nat Rev Immunol 8, 81–86 (2008). https://doi.org/10.1038/nri2225
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DOI: https://doi.org/10.1038/nri2225
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