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This study provides additional evidence that autosomal dominant mutations in AIRE can predispose to autoimmunity and may be more widespread than initially thought.
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This study provides evidence for a mechanism by which AIRE may recognize TSA target genes, involving the ATF7IP–MBD1 repressive complex.
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This study further clarifies a peripheral cell population that expresses AIRE and may tolerize CD4+ T cells through an anergic mechanism.
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This interesting study shows that thymic B cells can acquire AIRE expression through a RANK signalling mechanism.
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References 24 and 25 identify a highly conserved non-coding sequence that is crucial for the expression of thymic Aire. The sequence contains two conserved NF-κB responsive elements that may link RANK signalling to this element.
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References 30 and 31 use state-of-the-art single-cell transcript sequencing to further characterize the properties of TSA expression in mTECs.
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This study uses a cell-sorting approach to capture pools of distinct mTECs on the basis of their TSA expression and provides evidence that TSA expression involves coordination of distinct regions of the chromatin in each cell.
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This recent study suggests that a unique, early repertoire of TReg cells is generated in the thymus and seeds tissues to help maintain tolerance.
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References 28, 60 and 61 are recent studies that identify unique individual TCRs that are preferentially recruited into the TReg cell lineage in the thymus by AIRE.
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In this paper, the authors demonstrate that the acquisition of AIRE expression in a skin tumour model may help to promote tumorigenesis and suggest a function for AIRE aside from thymic TSA expression.
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This new study describes FEZ family zinc finger protein 2 (FEZF2) as a novel regulator of thymic TSA expression that complements the function of AIRE.
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