The stability of the neuronal circuits and cells of the enteric nervous system can no longer be taken for granted; new evidence suggests astounding rates of apoptosis and neurogenesis.
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References
Gianino, S., Grider, J. R., Cresswell, J., Enomoto, H. & Heuckeroth, R. O. GDNF availability determines enteric neuron number by controlling precursor proliferation. Development 130, 2187–2198 (2003).
Joseph, N. M. et al. Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut. J. Clin. Invest. 121, 3398–3411 (2011).
Laranjeira, C. et al. Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury. J. Clin. Invest. 121, 3412–3424 (2011).
Pham, T. D., Gershon, M. D. & Rothman, T. P. Time of origin of neurons in the murine enteric nervous system: sequence in relation to phenotype. J. Comp. Neurol. 314, 789–798 (1991).
Bergner, A. J. et al. Birthdating of myenteric neuron subtypes in the small intestine of the mouse. J. Comp. Neurol. 522, 514–527 (2014).
Liu, M. T., Kuan, Y. H., Wang, J., Hen, R. & Gershon, M. D. 5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. J. Neurosci. 29, 9683–9699 (2009).
Kulkarni, S. et al. Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis. Proc. Natl Acad. Sci. USA 114, E3709–E3718 (2017).
White, F. A., Keller-Peck, C. R., Knudson, C. M., Korsmeyer, S. J. & Snider, W. D. Widespread elimination of naturally occurring neuronal death in Bax-deficient mice. J. Neurosci. 18, 1428–1439 (1998).
Boesmans, W., Lasrado, R., Vanden Berghe, P. & Pachnis, V. Heterogeneity and phenotypic plasticity of glial cells in the mammalian enteric nervous system. Glia 63, 229–241 (2014).
Rao, M. et al. Enteric glia express proteolipid protein 1 and are a transcriptionally unique population of glia in the mammalian nervous system. Glia 63, 2040–2057 (2015).
Acknowledgements
M.R. acknowledges support from NIH National Institute of Diabetes & Digestive & Kidney Diseases grant DK110532. M.D.G. acknowledges support from NIH National Institute of Neurological Disorders and Stroke grant NS15547, NIH National Institute of Diabetes & Digestive & Kidney Diseases grant DK093094 and the Einhorn Family Charitable Trust.
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Rao, M., Gershon, M. The dynamic cycle of life in the enteric nervous system. Nat Rev Gastroenterol Hepatol 14, 453–454 (2017). https://doi.org/10.1038/nrgastro.2017.85
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DOI: https://doi.org/10.1038/nrgastro.2017.85
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