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Helicobacter pylori

Pathogenic enablers — toxic relationships in the stomach

Nature Reviews Gastroenterology & Hepatology volume 13, pages 317–318 (2016)Cite this article

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Chronic infection with Helicobacter pylori is the strongest known risk factor for the development of gastric cancer. Saju et al. shed new light on mechanisms by which Epstein–Barr virus, a viral initiator of gastric cancer, potentiates the oncogenic effects of Helicobacter pylori in the stomach.

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Figure 1: Co-infection with Helicobacter pylori and EBV in gastric epithelial cells promotes the oncogenic activity of CagA.

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Authors and Affiliations

  1. Division of Gastroenterology, Vanderbilt University School of Medicine, 1030C MRB IV, 2215B Garland Avenue, Nashville, 37232, Tennessee, USA

    Lydia E. Wroblewski & Richard M. Peek Jr

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  1. Lydia E. Wroblewski
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  2. Richard M. Peek Jr
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Correspondence to Richard M. Peek Jr.

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The authors declare no competing financial interests.

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Wroblewski, L., Peek, R. Pathogenic enablers — toxic relationships in the stomach. Nat Rev Gastroenterol Hepatol 13, 317–318 (2016). https://doi.org/10.1038/nrgastro.2016.68

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