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Gut microbiota in 2015

Prevotella in the gut: choose carefully

Nature Reviews Gastroenterology & Hepatology volume 13, pages 69–70 (2016)Cite this article

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Gut microbial communities often contain many Bacteroides or their close relatives, Prevotella, but not both. Prevotella strains are associated with plant-rich diets but are also linked with chronic inflammatory conditions. In 2015, papers probed the genomic diversity of Prevotella strains and interactions of Prevotella copri with its host and other bacteria.

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References

  1. Kovatcheva-Datchary, P. et al. Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of Prevotella. Cell Metab. 22, 971–982 (2015).

    Article  CAS  PubMed  Google Scholar 

  2. Martínez, I. et al. The gut microbiota of rural Papua New Guineans: composition, diversity patterns, and ecological processes. Cell Rep. 11, 527–538 (2015).

    Article  PubMed  Google Scholar 

  3. Wu, G. D. et al. Linking long-term dietary patterns with gut microbial enterotypes. Science 334, 105–108 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Scher, J. U. et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLIFE 2, e01202 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Dillon, S. M. et al. Gut dendritic cell activation links an altered colonic microbiome to mucosal and systemic T-cell activation in untreated HIV-1 infection. Mucosal Immunol. 9, 24–37 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Accetto, T. & Avguštin, G. Polysaccharide utilization locus and CAZYme genome repertoires reveal diverse ecological adaptation of Prevotella species. Syst. Appl. Microbiol. 38, 453–461 (2015).

    Article  CAS  PubMed  Google Scholar 

  7. De Filippis, F. et al. High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome. Gut http://dx.doi.org/10.1136/gutjnl-2015-309957 (2015).

  8. Gupta, V. et al. Divergence in gene repertoire among reference Prevotella genomes derived from distinct body sites of human. BMC Genomics 16, 153 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Zhu, A., Sunagawa, S., Mende, D. & Bork, P. Inter-individual differences in the gene content of human gut bacterial species. Genome Biol. 16, 82 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Lozupone, C. A. et al. HIV-induced alteration in gut microbiota: driving factors, consequences, and effects of antiretroviral therapy. Gut Microbes 5, 562–570 (2014).

    Article  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Ruth Ley is at Department of Molecular Biology and Genetics, USA and Department of Microbiome Science, 467 Biotech, Cornell University, Ithaca, New York 14853, Max Planck Institute for Developmental Biology, Spemannstrasse 35, Tübingen 72076, Germany.,

    Ruth E. Ley

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  1. Ruth E. Ley
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Correspondence to Ruth E. Ley.

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The author declares no competing financial interests.

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Jain, N. & Walker, W. A. Diet and host–microbial crosstalk in postnatal intestinal immune homeostasis. Nat. Rev. Gastroenterol. Hepatol. 12, 14–25 (2015)

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Ley, R. Prevotella in the gut: choose carefully. Nat Rev Gastroenterol Hepatol 13, 69–70 (2016). https://doi.org/10.1038/nrgastro.2016.4

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