Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Liver

DNA methylation controls liver fibrogenesis

New analysis reveals that activation of hepatic stellate cells, the key process driving liver fibrosis, is regulated through epigenetic mechanisms, including DNA methylation and hydroxymethylation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Cellular mechanisms of liver fibrosis and alteration of the DNA methylome during fibrogenesis.

References

  1. Bataller, R. & Brenner, D. A. Liver fibrosis. J. Clin. Invest. 115, 209–218 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Egger, G., Liang, G. N., Aparicio, A. & Jones, P. A. Epigenetics in human disease and prospects for epigenetic therapy. Nature 429, 457–463 (2004).

    Article  CAS  PubMed  Google Scholar 

  3. Page, A. et al. Hepatic stellate cell transdifferentiation involves genome-wide remodeling of the DNA methylation landscape. J. Hepatol. http://dx.doi.org/10.1016/j.jhep.2015.11.024 (2015).

  4. Hernandez-Gea, V. & Friedman, S. L. Pathogenesis of liver fibrosis. Annu. Rev. Pathol. 6, 425–456 (2011).

    Article  CAS  PubMed  Google Scholar 

  5. Kisseleva, T. & Brenner, D. A. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J. Gastroenterol. Hepatol. 22, S73–S78 (2007).

    Article  CAS  PubMed  Google Scholar 

  6. Iwaisako, K. et al. Origin of myofibroblasts in the fibrotic liver in mice. Proc. Natl Acad. Sci. USA 111, E3297–E3305 (2014).

    Article  CAS  PubMed  Google Scholar 

  7. Mann, D. A. & Mann, J. Epigenetic regulation of hepatic stellate cell activation. J. Gastroenterol. Hepatol. 23, S108–S111 (2008).

    Article  CAS  PubMed  Google Scholar 

  8. Mann, J. et al. Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis. Cell Death Differ. 14, 275–285 (2007).

    Article  CAS  PubMed  Google Scholar 

  9. Murphy, S. K. et al. Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease. Gastroenterology 145, 1076–1087 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Zeybel, M. et al. Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease. Clin. Epigenetics 7, 25 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to David A. Brenner.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liu, X., Brenner, D. DNA methylation controls liver fibrogenesis. Nat Rev Gastroenterol Hepatol 13, 126–128 (2016). https://doi.org/10.1038/nrgastro.2016.16

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrgastro.2016.16

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing