A randomized, double-blind, placebo-controlled trial has analyzed the potential benefit of supplementation with vitamin D, calcium or both in the prevention of colorectal adenomas. A cohort of 2,259 participants with recently diagnosed and removed adenomas received daily vitamin D3 (1,000 IU), calcium as carbonate (1,200 mg) or both with follow-up colonoscopies 3 or 5 years after the start of the therapy. The reduced risk of recurrent colorectal adenoma was not statistically significant under this regimen and few serious adverse events were reported.
References
Baron, J.A. et al. A trial of calcium and vitamin D for the prevention of colorectal adenomas. NEJM 10.1056/NEJMoa1500409
Rights and permissions
About this article
Cite this article
Vitamin D and calcium do not prevent adenoma recurrence. Nat Rev Gastroenterol Hepatol 12, 670 (2015). https://doi.org/10.1038/nrgastro.2015.198
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrgastro.2015.198