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NAFLD

Metabolic make-up of NASH: from fat and sugar to amino acids

Nature Reviews Gastroenterology & Hepatology volume 11, pages 205–207 (2014)Cite this article

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NAFLD is regarded unquestionably as one of the components of the metabolic syndrome. Hence, metabolic perturbations occurring in the fatty liver become a systemic metabolic derangement. The phenotypic switching from fatty liver to NASH entails a reprogramming of liver metabolism to fit a stressful metabolic environment.

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Figure 1: Proposed hypothesis regarding metabolic changes associated with NAFLD progression and the prediction of protein–chemical interactions based on metabolic modelling.

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Acknowledgements

The authors are partially supported by grants PICT 2010-0441 and PICT 2012-159 (Agencia Nacional de Promoción Científica y Tecnológica), and UBACYT CM04 (Universidad de Buenos Aires). S.S. and C.J.P. belong to Consejo Nacional de Investigaciones Científicas (CONICET).

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Authors and Affiliations

  1. Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires–National Scientific and Technical Research Council (CONICET), Combatiente de Malvinas 3150, Ciudad Autónoma de Buenos Aires 1427, Argentina

    Silvia Sookoian

  2. Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires–National Scientific and Technical Research Council (CONICET), Combatiente de Malvinas 3150, Ciudad Autónoma de Buenos Aires 1427, Argentina

    Carlos J. Pirola

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  1. Silvia Sookoian
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Correspondence to Silvia Sookoian.

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Sookoian, S., Pirola, C. Metabolic make-up of NASH: from fat and sugar to amino acids. Nat Rev Gastroenterol Hepatol 11, 205–207 (2014). https://doi.org/10.1038/nrgastro.2014.25

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