A new genome-wide association study has identified four novel loci associated with eosinophilic oesophagitis. Two of these loci have been previously associated with atopic and autoimmune diseases (c11orf30 and STAT6); meanwhile, ANKRD27 regulates the trafficking of melanogenic enzymes to epidermal melanocytes and CAPN14 encodes a calpain that is highly enriched in the oesophagus. The researchers suggest that these new loci might represent therapeutic targets for eosinophilic oesophagitis, namely oesophageal inflammation and remodelling.