Acute-on-chronic liver failure (ACLF) is a unique clinical entity that causes confusion amongst clinicians because no clear definition or standardized clinical features have been agreed worldwide. A recent comprehensive study provided an evidence-based definition and addressed its clinical features in patients with ACLF who have cirrhosis with acute decompensation.
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Acknowledgements
We appreciate the suggestions from Professor Shaojie Xin (Department of Liver Failure, Beijing 302 Hospital) and Professor Jidong Jia (Liver Research Center, Beijing Friendship Hospital) that helped in our writing of this article. This work was supported by a grant from the National Grand Program on Key Infectious Disease (2012ZX10002-007-002).
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Wang, FS., Zhang, Z. How can acute-on-chronic liver failure be accurately identified?. Nat Rev Gastroenterol Hepatol 10, 390–391 (2013). https://doi.org/10.1038/nrgastro.2013.72
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DOI: https://doi.org/10.1038/nrgastro.2013.72
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