Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

IBD

Elderly-onset IBD: a milder disease?

Patients with elderly-onset IBD are more likely to have marked comorbidities and polypharmacy than those diagnosed at a younger age, which might affect therapeutic decision-making. Increased knowledge of this higher-risk group might guide patient management. Data from a large population-based study evaluating the clinical presentation and course of elderly-onset IBD are discussed.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Census Data on Aging. US Department of Health and Human Services. Administration on Aging [online] (2011).

  2. Molodecky N. A. et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology 142, 46–54 (2012).

    Article  Google Scholar 

  3. Loftus, E. V. et al. Ulcerative colitis in Olmsted County, Minnesota, 1940–1993: incidence, prevalence, and survival. Gut 46, 336–343 (2000).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Loftus E. V. et al. Crohn's disease in Olmsted County, Minnesota, 1940–1993: incidence, prevalence, and survival. Gastroenterology 114, 1161–1168 (1998).

    Article  PubMed  Google Scholar 

  5. Katz, S. & Pardi, D. S. Inflammatory bowel disease of the elderly: frequently asked questions (FAQs). Am. J. Gastroenterol. 106, 1889–1897 (2011).

    Article  PubMed  Google Scholar 

  6. Charpentier, C. et al. Natural history of elderly-onset inflammatory bowel disease: a population-based cohort study. Gut http://dx.doi.org/10.1136/gutjnl-2012-303864.

  7. The burden of digestive diseases in the United States. NIDDK National Institute of Diabetes and Digestive and Kidney Diseases [online] (2008).

  8. Ananthakrishnan, A. N., McGinley, E. L. & Binion, D. G. Inflammatory bowel disease in the elderly is associated with worse outcomes: a national study of hospitalizations. Inflamm. Bowel Dis. 15, 182–189 (2009).

    Article  PubMed  Google Scholar 

  9. Deuring, J. J. et al. Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding. Biochem. J. 441, 87–93 (2012).

    Article  CAS  PubMed  Google Scholar 

  10. Robertson, D. J. & Grimm, I. S. Inflammatory bowel disease in the elderly. Gastrointest. Clin. North Am. 30, 409–426 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Seymour Katz.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ha, C., Katz, S. Elderly-onset IBD: a milder disease?. Nat Rev Gastroenterol Hepatol 10, 264–265 (2013). https://doi.org/10.1038/nrgastro.2013.56

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrgastro.2013.56

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing