Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

IBD

Poor outcomes after Clostridium difficile infection in IBD

Nature Reviews Gastroenterology & Hepatology volume 9, pages 307–308 (2012)Cite this article

Subjects

Clostridium difficile infection (CDI) is a common complication of IBD and is associated with disease flare-ups and adverse outcomes. Low levels of serum albumin and haemoglobin alongside high concentrations of serum creatinine predict the need for surgery and risk of death associated with CDI in patients with IBD.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Khanna, S. & Pardi D. S. The growing incidence and severity of Clostridium difficile infection in inpatient and outpatient settings. Expert Rev. Gastroenterol. Hepatol. 4, 409–416 (2010).

    Article  PubMed  Google Scholar 

  2. Khanna, S. et al. The epidemiology of community-acquired Clostridium difficile infection: a population-based study. Am. J. Gastroenterol. 107, 89–95 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Ananthakrishnan, A. N., McGinley, E. L. & Binion, D. G. Excess hospitalisation burden associated with Clostridium difficile in patients with inflammatory bowel disease. Gut 57, 205–210 (2008).

    Article  CAS  PubMed  Google Scholar 

  4. Ananthakrishnan, A. N. et al. Predictors of severe outcomes associated with Clostridium difficile infection in patients with inflammatory bowel disease. Aliment. Pharmacol. Ther. 35, 789–795 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Nguyen, G. C., Kaplan, G. G., Harris, M. L. & Brant, S. R. A national survey of the prevalence and impact of Clostridium difficile infection among hospitalized inflammatory bowel disease patients. Am. J. Gastroenterol. 103, 1443–1450 (2008).

    Article  PubMed  Google Scholar 

  6. Ananthakrishnan, A. N., McGinley, E. L., Saeian, K. & Binion, D. G. Temporal trends in disease outcomes related to Clostridium difficile infection in patients with inflammatory bowel disease. Inflamm. Bowel Dis. 17, 976–983 (2011).

    Article  PubMed  Google Scholar 

  7. Issa, M. et al. Impact of Clostridium difficile on inflammatory bowel disease. Clin. Gastroenterol. Hepatol. 5, 345–351 (2007).

    Article  PubMed  Google Scholar 

  8. Lungulescu, O. A., Cao, W., Gatskevich, E., Tlhabano, L. & Stratidis, J. G. CSI: a severity index for Clostridium difficile infection at the time of admission. J. Hosp. Infect. 79, 151–154 (2011).

    Article  CAS  PubMed  Google Scholar 

  9. Ben-Horin, S. et al. Combination immunomodulator and antibiotic treatment in patients with inflammatory bowel disease and Clostridium difficile infection. Clin. Gastroenterol. Hepatol. 7, 981–987 (2009).

    Article  PubMed  Google Scholar 

  10. Zar, F. A., Bakkanagari, S. R., Moorthi, K. M. & Davis, M. B. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clin. Infect. Dis. 45, 302–307 (2007).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, 55905, MN, USA

    Sahil Khanna & Darrell S. Pardi

Authors
  1. Sahil Khanna
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Darrell S. Pardi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Darrell S. Pardi.

Ethics declarations

Competing interests

S. Khanna declares no competing interests. D. S. Pardi has acted as a consultant for Optimer Pharmaceuticals.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Khanna, S., Pardi, D. Poor outcomes after Clostridium difficile infection in IBD. Nat Rev Gastroenterol Hepatol 9, 307–308 (2012). https://doi.org/10.1038/nrgastro.2012.87

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrgastro.2012.87

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing