Ciclosporin and infliximab are used as rescue therapies for the treatment of severe steroid-refractory ulcerative colitis. Now, an open-label, head-to-head randomized controlled trial has demonstrated that these drugs are well-tolerated and have equivalent efficacy in inducing short-term clinical response, mucosal healing and decreasing colectomy rates at 3 months.
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Kaur, M., Targan, S. Steroid-refractory ulcerative colitis—ciclosporin or infliximab?. Nat Rev Gastroenterol Hepatol 10, 8–9 (2013). https://doi.org/10.1038/nrgastro.2012.235
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DOI: https://doi.org/10.1038/nrgastro.2012.235