Given the early onset of ulcerative colitis in children, it is desirable to identify young patients with this disease who are at risk of adverse outcomes. Identification of these patients would enable the introduction of disease-modifying therapies early in the disease course and thus prevent the need for surgical therapy.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Van Limbergen, J. et al. Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology 135, 1114–1122 (2008).
Shikhare, G. & Kugathasan, S. Inflammatory bowel disease in children: current trends. J. Gastroenterol. 45, 673–682 (2010).
Ruemmele, F. M. Pediatric inflammatory bowel diseases: coming of age. Curr. Opin. Gastroenterol. 26, 332–336 (2010).
Kelley-Quon, L. I. et al. Predictors of proctocolectomy in children with ulcerative colitis. J. Pediatr. Gastroenterol. Nutr. http://dx.doi.org/10.1097/MPG.0b013e3182619d26.
Gower-Rousseau, C. et al. The natural history of pediatric ulcerative colitis: a population-based cohort study. Am. J. Gastroenterol. 104, 2080–2088 (2009).
Moore, J. C. et al. Clinical variables as prognostic tools in pediatric-onset ulcerative colitis: a retrospective cohort study. Inflamm. Bowel. Dis. 17, 15–21 (2011).
Travis, S., Feagan, B. G., Rutheerts, P. & van Deventer, S. The future of inflammatory bowel disease management: combining progress in trial design with advances in targeted therapy. J. Crohns Colitis 6 (Suppl. 2), S250–S259 (2012).
Colombel, J. F. et al. Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis. Gastroenterology 142, 1194–1201 (2011).
Ho, G. T. et al. The efficacy of corticosteroid therapy in inflammatory bowel disease: analysis of a 5-year UK inception cohort. Aliment. Pharmacol. Ther. 15, 319–330 (2006).
Hyams, J. et al. The natural history of corticosteroid therapy for ulcerative colitis in children. Clin. Gastroenterol. Hepatol. 4, 1118–1123 (2006).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Cucchiara, S., Stronati, L. Paediatric ulcerative colitis—can we predict proctocolectomy?. Nat Rev Gastroenterol Hepatol 9, 494–495 (2012). https://doi.org/10.1038/nrgastro.2012.153
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrgastro.2012.153