5-Aminosalicylates are used as maintenance therapy in patients with ulcerative colitis. However, compliance rates are low. Ford et al. conducted a meta-analysis to investigate whether once-daily dosing with mesalamine, which might improve compliance, is as effective as conventional dosing schedules. They found that once-daily dosing is as effective as conventional dosing for preventing relapse, although no evidence indicated that compliance with once-daily dosing was better.
ORIGINAL RESEARCH PAPER
Ford, A. C. et al. Once-daily dosing vs. conventional dosing schedule of mesalamine and relapse of quiescent ulcerative colitis: systematic review and meta-analysis. Am. J. Gastroenterol. doi: 10.1038/ajg.2011.296
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Effectiveness of once-daily dosing with mesalamine for maintenance therapy in ulcerative colitis. Nat Rev Gastroenterol Hepatol 8, 602 (2011). https://doi.org/10.1038/nrgastro.2011.182
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DOI: https://doi.org/10.1038/nrgastro.2011.182