5-Aminosalicylates are used as maintenance therapy in patients with ulcerative colitis. However, compliance rates are low. Ford et al. conducted a meta-analysis to investigate whether once-daily dosing with mesalamine, which might improve compliance, is as effective as conventional dosing schedules. They found that once-daily dosing is as effective as conventional dosing for preventing relapse, although no evidence indicated that compliance with once-daily dosing was better.