In a large, randomized, controlled trial conducted in the UK, screening flexible sigmoidsocopy led to substantial reductions in the incidence of and mortality from distal colorectal cancer. Both fecal occult blood testing and flexible sigmoidoscopy screening are now proven to reduce colorectal cancer mortality.
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References
Atkin, W. S. et al. Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial. Lancet 375, 1624–1633 (2010).
Hoff, G., Grotmol, T., Skovlund, E. & Bretthauer, M. Risk of colorectal cancer seven years after flexible sigmoidoscopy screening: randomised controlled trial. BMJ 338, b1846 (2009).
Weissfeld, J. L. et al. Flexible sigmoidoscopy in the PLCO cancer screening trial: results from the baseline screening examination of a randomized trial. J. Natl Cancer Inst. 97, 989–997 (2005).
Segnan, N. et al. Baseline findings of the Italian multicenter randomized controlled trial of “once-only sigmoidoscopy”—SCORE. J. Natl Cancer Inst. 94, 1763–1772 (2002).
Mandel, J. S. et al. Reducing mortality from colorectal cancer by screening for fecal occult blood. Minnesota Colon Cancer Control Study. N. Engl. J. Med. 328, 1365–1371 (1993).
ClinicalTrials.gov The Northern-European Initiative on Colorectal Cancer (NordICC) [online], (2010).
Arain, M. A. et al. CIMP status of interval colon cancers: another piece to the puzzle. Am. J. Gastroenterol. 105, 1189–1195 (2010).
Rex, D. K. et al. Quality indicators for colonoscopy. Gastrointest. Endosc. 63 (Suppl.), S16–S28 (2006).
Kaminski, M. F. et al. Quality indicators for colonoscopy and the risk of interval cancer. N. Engl. J. Med. 362, 1795–1803 (2010).
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D. K. Rex declares an association with Olympus America. He is a speaker for Olympus America and has received grant and research support from Olympus America.
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Rex, D. Screening flexible sigmoidoscopy effective in a UK RCT. Nat Rev Gastroenterol Hepatol 7, 423–424 (2010). https://doi.org/10.1038/nrgastro.2010.111
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DOI: https://doi.org/10.1038/nrgastro.2010.111
