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Celiac disease

Diagnosis of celiac disease in pediatric patients

Nature Reviews Gastroenterology & Hepatology volume 6, pages 260–262 (2009)Cite this article

Children and adolescents with untreated celiac disease display disease-related, histological alterations in the duodenal bulb, according to a new study. In 16 of the 665 patients enrolled in the study, lesions were confined to the duodenal bulb.

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References

  1. Rostom, A. et al. American gastroenterological association (AGA) institute technical review on the diagnosis and management of celiac disease. Gastroenterology 131, 1981–2002 (2006).

    Article  Google Scholar 

  2. Hill, I. D. et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American society for pediatric gastroenterology, hepatology and nutrition. J. Pediatr. Gastroenterol. Nutr. 40, 1–19 (2005).

    Article  Google Scholar 

  3. Green, P. H. & Cellier, C. Celiac disease. N. Engl. J. Med. 357, 1731–1743 (2007).

    Article  CAS  Google Scholar 

  4. Ravelli, A. et al. Variability of histologic lesions in relation to biopsy site in gluten-sensitive enteropathy. Am. J. Gastroenterol. 100, 177–185 (2005).

    Article  Google Scholar 

  5. Bonamico, M. et al. Patchy villous atrophy of the duodenum in childhood celiac disease. J. Pediatr. Gastroenterol. Nutr. 38, 204–207 (2004).

    Article  Google Scholar 

  6. Bonamico, M. et al. Duodenal bulb biopsies in celiac disease: a multicenter study. J. Pediatr. Gastroenterol. Nutr. 47, 618–622 (2008).

    Article  Google Scholar 

  7. Murray, J. A. et al. Mucosal atrophy in celiac disease: extent of involvement, correlation with clinical presentation, and response to treatment. Clin. Gastroenterol. Hepatol. 6, 186–193 (2008).

    Article  Google Scholar 

  8. Cameron, A. H. et al. Duodeno-jejunal biopsy in the investigation of children with coeliac disease. Q. J. Med. 31, 125–140 (1962).

    CAS  PubMed  Google Scholar 

  9. Mee, A. S. et al. Small bowel biopsy for malabsorption: comparison of the diagnostic adequacy of endoscopic forceps and capsule biopsy specimens. Br. Med. J. (Clin. Res. Ed.) 291, 769–772 (1985).

    Article  CAS  Google Scholar 

  10. Macdonald, W. C. et al. Studies of celiac sprue. IV. The response of the whole length of the small bowel to a gluten-free diet. Gastroenterology 47, 573–589 (1964).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This article was supported by the National Institute of Health under Ruth L. Kirschstein National Research Service Award/Training Grant in Gastrointestinal Allergy and Immunology (T32 AI-07,047, awarded to A. Rubio-Tapia) and the National Institute of Health grants DK-57,892 and DK-070,031 (awarded to J. A. Murray).

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  1. Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA

    Joseph A. Murray, Shadi Rashtak & Alberto Rubio-Tapia

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  1. Joseph A. Murray
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  2. Shadi Rashtak
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  3. Alberto Rubio-Tapia
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Correspondence to Alberto Rubio-Tapia.

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Murray, J., Rashtak, S. & Rubio-Tapia, A. Diagnosis of celiac disease in pediatric patients. Nat Rev Gastroenterol Hepatol 6, 260–262 (2009). https://doi.org/10.1038/nrgastro.2009.58

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