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Incidence of HSV and HPV with azathioprine

Nature Reviews Gastroenterology & Hepatology volume 6, pages 444–445 (2009)Cite this article

Severe infections are an established risk of immunosuppressive therapy; however, the risk of opportunistic infections in patients with IBD who receive immunosuppressive therapy has so far only been studied retrospectively. The increased incidence of herpes flares and development or worsening of viral warts in patients with IBD who receive azathioprine has now been demonstrated for the first time in a prospective study.

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References

  1. Toruner, M. et al. Risk factors for opportunistic infections in patients with inflammatory bowel disease. Gastroenterology 134, 929–936 (2008).

    Article  Google Scholar 

  2. Lichtenstein, G. R. et al. Serious infections and mortality in association with therapies for Crohn's disease: TREAT registry. Clin. Gastroenterol. Hepatol. 4, 621–630 (2006).

    Article  CAS  Google Scholar 

  3. Beaugerie, L. et al. The use of immunomodulators and biologics in inflammatory bowel diseases (IBD): a cross-sectional French nationwide cohort 2004–2005 [Abstract]. Gastroenterology 130 (4 Suppl. 2), A2 (2006).

    Google Scholar 

  4. Kane, S., Khatibi, B. & Reddy, D. Higher incidence of abnormal Pap smears in women with inflammatory bowel disease. Am. J. Gastroenterol. 103, 631–636 (2008).

    Article  Google Scholar 

  5. Korelitz, B. I., Fuller, S. R., Warman, J. I. & Goldberg, M. D. Shingles during the course of treatment with 6-mercaptopurine for inflammatory bowel disease. Am. J. Gastroenterol. 94, 424–426 (1999).

    Article  CAS  Google Scholar 

  6. Gupta, G., Lautenbach, E. & Lewis, J. D. Incidence and risk factors for herpes zoster among patients with inflammatory bowel disease. Clin. Gastroenterol. Hepatol. 4, 1483–1490 (2006).

    Article  Google Scholar 

  7. Seksik, P. et al. Incidence of benign upper respiratory tract infections, HSV and HPV cutaneous infections in inflammatory bowel disease patients treated with azathioprine. Aliment. Pharmacol. Ther. 29, 1106–1113 (2009).

    Article  CAS  Google Scholar 

  8. Spencer, E. S. & Andersen, H. K. Viral infections in renal allograft recipients treated with long-term immunosuppression. Br. Med. J. 2, 829–830 (1979).

    Article  CAS  Google Scholar 

  9. Warman, J. I., Korelitz, B. I., Fleisher, M. R. & Janardhanam, R. Cumulative experience with short- and long-term toxicity to 6-mercaptopurine in the treatment of Crohn's disease and ulcerative colitis. J. Clin. Gastroenterol. 37, 220–225 (2003).

    Article  CAS  Google Scholar 

  10. Viget, N., Vernier-Massouille, G., Salmon-Ceron, D., Yazdanpanah, Y. & Colombel, J. F. Opportunistic infections in patients with inflammatory bowel disease: prevention and diagnosis. Gut 57, 549–558 (2008).

    Article  CAS  Google Scholar 

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  1. Dipartimento di Medicina, Pneumologia e Fisiologia della Nutrizione, Università di Palermo, Palermo, Italy

    Mario Cottone & Sara Renna

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  1. Mario Cottone
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  2. Sara Renna
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Correspondence to Mario Cottone.

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Cottone, M., Renna, S. Incidence of HSV and HPV with azathioprine. Nat Rev Gastroenterol Hepatol 6, 444–445 (2009). https://doi.org/10.1038/nrgastro.2009.110

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