The recovery of transcription after genotoxic stress is crucial for cells. Here, the authors show that the histone chaperone HIRA deposits histone H3.3 to sites of ultraviolet C irradiation before these sites are repaired, in a manner that is dependent on local chromatin ubiquitylation events after such damage. This early function of HIRA is required for transcriptional activation after repair, and the authors propose that it acts as a chromatin 'bookmark' for transcription recovery.
References
Adam, S., Polo, S. E. & Almouzni, G. Transcription recovery after DNA damage requires chromatin priming by the H3.3 histone chaperone HIRA. Cell 155, 94–106 (2013)
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Stower, H. H3.3 recovers transcription. Nat Rev Genet 14, 747 (2013). https://doi.org/10.1038/nrg3615
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DOI: https://doi.org/10.1038/nrg3615
