Although some tRNAs can be processed into other small RNAs, the functions of these fragments are generally poorly defined. Maute et al. showed that the tRNA-derived fragment CU1276 exhibits various properties of a functional microRNA and is downregulated in B cell lymphoma relative to normal B cells. CU1276 was also found to repress the expression of replication protein A1 (RPA1) as a potential tumour suppressive mechanism to limit cell proliferation and modulate the DNA damage response.
ORIGINAL RESEARCH PAPER
Maute, R. L. et al. tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma. Proc. Natl Acad. Sci. USA 110, 1404–1409 (2013)
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Burgess, D. A tumour-suppressive tRNA fragment. Nat Rev Genet 14, 152 (2013). https://doi.org/10.1038/nrg3440
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DOI: https://doi.org/10.1038/nrg3440
