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Genome architecture

Reliable repositioning in cancer

Nature Reviews Genetics volume 11, pages 92–93 (2010)Cite this article

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“If these results can be extended to a larger number and variety of tissue types, they could represent a novel cancer diagnostic that uses sample preparation techniques that are similar to those already available in clinical laboratories.”

A substantial body of papers over the past five years have shown that gene positioning in cells is not random; the spatial placement of DNA in the nucleus offers another layer of information conveyed by the human genome. This arrangement of DNA has been shown to change in normal processes, such as differentiation, as well as in the abnormal state of multiple cancers.

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References

ORIGINAL RESEARCH PAPER

  1. Meaburn, K. J., Gudla, P. R., Khan, S., Lockett, S. J. & Misteli, T. Disease-specific gene repositioning in breast cancer. J. Cell Biol. 187, 801–812 (2009)

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FURTHER READING

  1. Lanctôt, C., Cheutin, T., Cremer, M., Cavalli, G. & Cremer, T. Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions. Nature Rev. Genet. 8, 104–115 (2007)

    Article  Google Scholar 

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  1. HudsonAlpha Institute for Biotechnology,

    Chris Gunter

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  1. Chris Gunter
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Gunter, C. Reliable repositioning in cancer. Nat Rev Genet 11, 92–93 (2010). https://doi.org/10.1038/nrg2742

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