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A new approach to microarrays

Nature Reviews Genetics volume 5, pages 411–412 (2004)Cite this article

Unlike conventional microarrays, the location of probes on randomly assembled microarrays is unknown. However, random assembly allows more effective miniaturization and higher packing densities to be achieved, which improves cost-effectiveness and statistical power. Until now, though, identifying the probes after assembly required complex dye chemistries and labelling processes, which limited attempts to develop randomly assembled microarrays.

Chee and colleagues have developed a simple and efficient algorithm that can accurately decode many thousands of DNA-linked objects, in this case, DNA-coated beads, using only a few labels and several sequential rounds of hybridization.

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ORIGINAL RESEARCH PAPER

  1. Gunderson, K. L. et al. Decoding randomly ordered DNA arrays. Genome Res. 14, 870–877 (2004)

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  1. Natalie Wilson
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Wilson, N. A new approach to microarrays. Nat Rev Genet 5, 411–412 (2004). https://doi.org/10.1038/nrg1373

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