Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Pituitary gland

Gamma Knife for Cushing disease — time for a reappraisal?

The first large-scale, multicentric analysis of long-term results with Gamma Knife (Elekta) radiosurgery in the therapeutically challenging area of Cushing disease shows that, in selected patients, this radiation technique enables hormonal control to be achieved in most patients with relatively few adverse effects but with a significant risk of disease recurrence.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Patil, C. G. et al. Late recurrences of Cushing's disease after initial successful transsphenoidal surgery. J. Clin. Endocrinol. Metab. 93, 358–362 (2008).

    Article  CAS  Google Scholar 

  2. Pivonello, R. et al. The treatment of Cushing's disease. Endocr. Rev. 36, 385–486 (2015).

    Article  CAS  Google Scholar 

  3. Guerin, C. et al. Bilateral adrenalectomy in the 21st century: when to use it for hypercortisolism? Endocr. Relat. Cancer 23, R131–R142 (2016).

    Article  CAS  Google Scholar 

  4. Hahner, S. et al. High incidence of adrenal crisis in educated patients with chronic adrenal insufficiency: a prospective study. J. Clin. Endocrinol. Metab. 100, 407–416 (2015).

    Article  CAS  Google Scholar 

  5. Castinetti, F. et al. Long-term results of stereotactic radiosurgery in secretory pituitary adenomas. J. Clin. Endocrinol. Metab. 94, 3400–3407 (2009).

    Article  CAS  Google Scholar 

  6. Mehta, G. U. et al. Stereotactic radiosurgery for Cushing's disease: results of an international, multicenter study. J. Clin. Endocrinol. Metab. http://dx.doi.org/10.1210/jc.2017-01385 (2017).

  7. Burman, P. et al. Radiotherapy, especially at young age, increases the risk for de novo brain tumors in patients treated for pituitary/sellar lesions. J. Clin. Endocrinol. Metab. 102, 1051–1058 (2017).

    PubMed  Google Scholar 

  8. Maione, L. et al. Changes in the management and comorbidities of acromegaly over three decades: the French Acromegaly Registry. Eur. J. Endocrinol. 176, 645–655 (2017).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors would like to thank the medical staff of the Reference Center for Rare Pituitary Diseases (HYPO), especially H. Dufour and J. Regis.

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Frederic Castinetti or Thierry Brue.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Castinetti, F., Brue, T. Gamma Knife for Cushing disease — time for a reappraisal?. Nat Rev Endocrinol 13, 628–629 (2017). https://doi.org/10.1038/nrendo.2017.130

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrendo.2017.130

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing