Type 2 diabetes mellitus (T2DM) is a major global health challenge. Development of more effective strategies for prevention and therapy depends on an improved understanding of its pathogenetic mechanisms. 2016 ends a period during which large-scale discovery of risk alleles for T2DM became routine and heralds a shift in research focus towards their exploitation to fuel mechanistic insights.
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References
Morris, A. P. et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat. Genet. 44, 981–990 (2012).
Fuchsberger, C. et al. The genetic architecture of type 2 diabetes. Nature 536, 41–47 (2016).
Moltke, I. et al. A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes. Nature 512, 190–193 (2014).
Minster, R. L. et al. A thrifty variant in CREBRF strongly influences body mass index in Samoans. Nat. Genet. 48, 1049–1054 (2016).
Lotta, L. A. Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat Genet. http://dx.doi.org./10.1038/ng.3714 (2016).
Gaulton, K. J. et al. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat. Genet. 47, 1415–1425 (2015).
Tuomi, T. et al. Increased melatonin signaling is a risk factor for type 2 diabetes. Cell Metab. 23, 1067–1077 (2016).
Bonnefond, A., Karamitri, A., Jockers, R. & Froguel, P. The difficult journey from genome-wide association studies to pathophysiology: the melatonin receptor 1B (MT2) paradigm. Cell Metab. 24, 345–347 (2016).
Pedersen, H. K. et al. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature 535, 376–381 (2016).
Bonder, M. J. et al. The effect of host genetics on the gut microbiome. Nat. Genet. 48, 1407–1412 (2016).
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M.I.McC. is a member of Advisory Boards at NovoNordisk and Pfizer. He has received honoraria from EliLilly, NovoNordisk and Pfizer, and research funding (via the Innovative Medicines Initiative and the Accelerating Medicines Partnership) from Abbvie, Astra Zeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Merck, NovoNordisk, Pfizer, Roche, Sanofi-Aventis, Servier and Takeda.
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McCarthy, M. Biological and translational insights from T2DM genetics. Nat Rev Endocrinol 13, 71–72 (2017). https://doi.org/10.1038/nrendo.2016.212
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DOI: https://doi.org/10.1038/nrendo.2016.212
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