Blood vessels in white adipose tissue (WAT) regulate β3-adrenergic and cold-induced beiging of WAT via a platelet-derived growth factor C (PDGFC)-mediated paracrine mechanism, according to new data. Global deletion of Pdgfc, endothelial-specific deletion of Kdr and pharmacological blockade of PDGFα all effectively prevented the WAT–beige transition. Conversely, PDGFC induced beiging of WAT and improved glucose tolerance and insulin sensitivity in high-fat-diet-induced obese mice. The PDGF pathway might, thus, be a potential therapeutic target for the treatment of obesity and other metabolic diseases, such as type 2 diabetes mellitus.