Gonadotropin-releasing hormone analogues (GnRHa) can improve adult height prospects in children with central precocious puberty (CPP). A recent report demonstrates that 50 mg histrelin subcutaneous implants are safe and effective when used yearly. However, questions remain regarding the use of GnRHa in girls with idiopathic CPP, who experience a slow progressive form of puberty.
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Familial early puberty: presentation and inheritance pattern in 139 families
BMC Endocrine Disorders Open Access 13 September 2016
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References
Carel, J. C. et al. Consensus statement on the use of gonadotropin-releasing hormone analogs in children. Pediatrics 123, e752–e762 (2009).
Chemaitilly, W. et al. Central precocious puberty: clinical and laboratory features. Clin. Endocrinol. (Oxf.) 54, 289–294 (2001).
Willemsen, R. H., Elleri, D., Williams, R. M., Ong, K. K. & Dunger, D. B. Pros and cons of GnRHa treatment for early puberty in girls. Nat. Rev. Endocrinol. 10, 352–363 (2014).
Eugster, E. A. et al. Efficacy and safety of histrelin subdermal implant in children with central precocious puberty: a multicenter trial. J. Clin. Endocrinol. Metab. 92, 1697–1704 (2007).
Silverman, L. A. et al. Long-term continuous suppression with once-yearly histrelin subcutaneous implants for the treatment of central precocious puberty: a final report of a phase 3 multicenter trial. J. Clin. Endocrinol. Metab. http://dx.doi.org/10.1210/jc.2014-3031.
Bayley, N. & Pinneau, S. R. Tables for predicting adult height from skeletal age: revised for use with the Greulich–Pyle hand standards. J. Pediatr. 40, 423–441 (1952).
Fontoura, M., Brauner, R., Prevot, C. & Rappaport, R. Precocious puberty in girls: early diagnosis of a slowly progressing variant. Arch. Dis. Child. 64, 1170–1176 (1989).
Oerter, K. E., Uriarte, M. M., Rose, S. R., Barnes, K. M. & Cutler, G. B. Jr. Gonadotropin secretory dynamics during puberty in normal girls and boys. J. Clin. Endocrinol. Metab. 71, 1251–1258 (1990).
Giabicani, E., Lemaire, P. & Brauner, R. Models for predicting the adult height and age at first menstruation of girls with idiopathic central precocious puberty. PLoS ONE 10, e0120588 (2015).
Bourayou, R., Giabicani, E., Pouillot, M., Brailly-Tabard, S. & Brauner, R. Premature pubarche before one year of age: distinguishing between mini-puberty variants and precocious puberty. Med. Sci. Monit. 21, 955–963 (2015).
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Brauner, R. Treatment of girls with central precocious puberty. Nat Rev Endocrinol 11, 386–387 (2015). https://doi.org/10.1038/nrendo.2015.65
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DOI: https://doi.org/10.1038/nrendo.2015.65
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Familial early puberty: presentation and inheritance pattern in 139 families
BMC Endocrine Disorders (2016)