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Antisenses working overtime in lipids

Nature Reviews Endocrinology volume 11, pages 574–576 (2015)Cite this article

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Antisense oligonucleotides have proven effective at preventing protein synthesis as a result of their on-target specificity. Recent data from several clinical trials including a phase I trial targeting Lp(a), published in The Lancet, highlight the therapeutic potential of antisense oligonucleotides in regulating plasma lipid levels.

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Figure 1: Targeted action of apo(a) ASO.

References

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Acknowledgements

R.A.H. is supported by grants from the Canadian Institutes of Health Research (Foundation Program), the Heart and Stroke Foundation (Project G-15-0009214), and Genome Canada (through Genome Quebec). S.M.K.F. is supported by the Canadian Institutes of Health Research Frederick Banting and Charles Best Canada Graduate Scholarship.

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  1. Departments of Biochemistry and Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, Room 4288, 1151 Richmond Street North, London, N6A 5K8, ON, Canada

    Sali M. K. Farhan & Robert A. Hegele

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  1. Sali M. K. Farhan
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  2. Robert A. Hegele
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Correspondence to Robert A. Hegele.

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Competing interests

R.A.H. consults for Aegerion, Amgen, Boston Heart Diagnostics, ISIS, Lilly, Merck, Pfizer, Sanofi and Valeant Pharmaceuticals. S.M.K.F. declares no competing interests.

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Farhan, S., Hegele, R. Antisenses working overtime in lipids. Nat Rev Endocrinol 11, 574–576 (2015). https://doi.org/10.1038/nrendo.2015.146

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