Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Year in Review
  • Published:

Treatment of pituitary tumours in 2014

Advances in therapy of adenomas secreting GH, ACTH and TSH

In 2014, many articles focusing on pituitary tumours were published, including studies on genetics, surgery, radiotherapy and medical treatment. This commentary highlights advances in the management of patients with acromegaly, Cushing disease and TSH-secreting tumours. Together, these advances will benefit the care and management of patients with pituitary tumours.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Giustina, A. et al. Expert consensus document: a consensus on the medical treatment of acromegaly. Nat. Rev. Endocrinol. 10, 243–248 (2014).

    Article  CAS  PubMed  Google Scholar 

  2. van der Hoek, J. et al. A single-dose comparison of the acute effects between the new somatostatin analog SOM230 and octreotide in acromegalic patients. J. Clin. Endocrinol. Metab. 89, 638–645 (2004).

    Article  CAS  PubMed  Google Scholar 

  3. Colao, A. et al. Pasireotide versus octreotide in acromegaly: a head-to-head superiority study. J. Clin. Endocrinol. Metab. 99, 791–799 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Henry, R. R. et al. Hyperglycemia associated with pasireotide: results from a mechanistic study in healthy volunteers. J. Clin. Endocrinol. Metab. 98, 3446–3453 (2013).

    Article  CAS  PubMed  Google Scholar 

  5. Newell-Price, J. et al. Cushing's syndrome. Lancet 367, 1605–1617 (2006).

    Article  CAS  PubMed  Google Scholar 

  6. Pivonello, R. et al. Pasireotide treatment significantly improves clinical signs and symptoms in patients with Cushing's disease: results from a phase III study. Clin. Endocrinol. (Oxf.) 81, 408–417 (2014).

    Article  CAS  Google Scholar 

  7. Petersenn, S. et al. High variability in baseline urinary free cortisol values in patients with Cushing's disease. Clin. Endocrinol. (Oxf.) 80, 261–269 (2014).

    Article  CAS  Google Scholar 

  8. Beck-Peccoz, P., Lania, A., Beckers, A., Chatterjee, K. & Wemeau, J. L. 2013 European thyroid association guidelines for the diagnosis and treatment of thyrotropin-secreting pituitary tumors. Eur. Thyroid J. 2, 76–82 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Gatto, F. et al. Clinical outcome and evidence of high rate post-surgical anterior hypopituitarism in a cohort of TSH-secreting adenoma patients: might somatostatin analogs have a role as first-line therapy? Pituitary http://dx.doi.org/10.1007/s11102-014-0611–8.

  10. Yamada, S. et al. Clinicopathological characteristics and therapeutic outcomes in thyrotropin-secreting pituitary adenomas: a single-center study of 90 cases. J. Neurosurg. 19, 1–12 (2014).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Annamaria Colao.

Ethics declarations

Competing interests

The author has received speaker honoraria and consultancy fees from Novartis in relation to the development of pasireotide for acromegaly.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Colao, A. Advances in therapy of adenomas secreting GH, ACTH and TSH. Nat Rev Endocrinol 11, 73–74 (2015). https://doi.org/10.1038/nrendo.2014.227

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrendo.2014.227

This article is cited by

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer