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Increased fracture risk with HIV infection—a growing concern

HIV infection and antiretroviral therapy have long been associated with an increased risk of osteopenia and osteoporosis. This predisposition has now been shown to result in a significantly increased risk of osteoporotic fractures in the HIV-infected population even after controlling for known risk factors.

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Figure 1: Determinants of increased fracture risk in patients with HIV infection.

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Acknowledgements

R. Bedimo is supported by VA MERIT grant I01 CX000418-01A1. P. Tebas is supported by grant AI045008.

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Correspondence to Pablo Tebas.

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Bedimo, R., Tebas, P. Increased fracture risk with HIV infection—a growing concern. Nat Rev Endocrinol 9, 260–261 (2013). https://doi.org/10.1038/nrendo.2013.62

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