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Diabetes

Targeting endoplasmic reticulum to combat juvenile diabetes

Nature Reviews Endocrinology volume 10, pages 129–130 (2014)Cite this article

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Limited options for clinical management of patients with juvenile-onset diabetes mellitus call for a novel therapeutic paradigm. Two innovative studies support endoplasmic reticulum as an emerging target for combating both autoimmune and heritable forms of this disease.

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Acknowledgements

F. Urano thanks the Washington University Wolfram Clinic, the Washington University Wolfram Study Group and participants in the Wolfram syndrome International Registry. F. Urano is supported by grants from the NIH (DK067493 and DK020579), Juvenile Diabetes Research Foundation (17-2013-512), American Diabetes Association (1-12-CT-61), Samuel E. Schechter Professorship, Ellie White Foundation for Rare Genetic Disorders, and the Jack and J. T. Snow Scientific Research Foundation.

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  1. Department of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8127, St Louis, 63110, MO, USA

    Fumihiko Urano

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  1. Fumihiko Urano
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Correspondence to Fumihiko Urano.

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Urano, F. Targeting endoplasmic reticulum to combat juvenile diabetes. Nat Rev Endocrinol 10, 129–130 (2014). https://doi.org/10.1038/nrendo.2013.261

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