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The gut microbiota manages host metabolism

Nature Reviews Endocrinology volume 10, pages 74–76 (2014)Cite this article

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In 2013, studies in rodents and humans have reaffirmed the essential role of the gut microbiota in host metabolism. More importantly, several converging results have increased our knowledge regarding the taxa and functions of the gut microbiota that contribute to the management of energy homeostasis, glucose metabolism and metabolic inflammation.

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Figure 1: Changes in gut microbiota composition and metabolism.

References

  1. Zhao, L. The gut microbiota and obesity: from correlation to causality. Nat. Rev. Microbiol. 11, 639–647 (2013).

    Article  CAS  Google Scholar 

  2. Turnbaugh, P. J. et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027–1031 (2006).

    Article  Google Scholar 

  3. Zhang, H. et al. Human gut microbiota in obesity and after gastric bypass. Proc. Natl Acad. Sci. USA 106, 2365–2370 (2009).

    Article  CAS  Google Scholar 

  4. Liou, A. P. et al. Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Sci. Transl. Med. 5, 178ra41 (2013).

    Article  Google Scholar 

  5. Ridaura, V. K. et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341, 1241214 (2013).

    Article  Google Scholar 

  6. Cotillard, A. et al. Dietary intervention impact on gut microbial gene richness. Nature 500, 585–588 (2013).

    Article  CAS  Google Scholar 

  7. Le Chatelier, E. et al. Richness of human gut microbiome correlates with metabolic markers. Nature 500, 541–546 (2013).

    Article  CAS  Google Scholar 

  8. Everard, A. et al. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes 60, 2775–2786 (2011).

    Article  CAS  Google Scholar 

  9. Everard, A. et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc. Natl Acad. Sci. USA 110, 9066–9071 (2013).

    Article  CAS  Google Scholar 

  10. Kimura, I. et al. The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat. Commun. 4, 1829 (2013).

    Article  Google Scholar 

Download references

Acknowledgements

P. D. Cani is a research associate from the FRS-FNRS (Fonds de la Recherche Scientifique) and a recipient of grants from the FNRS and FRSM (Fonds de la recherche scientifique médicale), Belgium, and of the European Research Council starting grant 2013 (336452-ENIGMO).

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  1. Université Catholique de Louvain, LDRI, Metabolism and Nutrition research group, WELBIO, Avenue E. Mounier, 73 box B1.73.11, Brussels, B-1200, Belgium

    Patrice D. Cani

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Correspondence to Patrice D. Cani.

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Cani, P. The gut microbiota manages host metabolism. Nat Rev Endocrinol 10, 74–76 (2014). https://doi.org/10.1038/nrendo.2013.240

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