Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Reproductive endocrinology

Estrogens—not just female hormones

Nature Reviews Endocrinology volume 9, pages 693–694 (2013)Cite this article

Subjects

In a carefully conducted, outstanding example of clinical research, Finkelstein et al. clearly demonstrate the physiological underpinnings for the action of testosterone and the relative roles of its androgenic and estrogenic effects on body composition and sexual function. This study has important clinical implications for testosterone replacement therapy of male hypogonadism.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Finkelstein, J. S. et al. Gonadal steroids and body composition, strength, and sexual function in men. N. Engl. J. Med. 369, 1011–1022 (2013).

    Article  CAS  Google Scholar 

  2. Khosla, S., Melton, L. J. 3rd & Riggs, B. L. Estrogen and the male skeleton. J. Clin. Endocrinol. Metab. 87, 1443–1450 (2002).

    Article  CAS  Google Scholar 

  3. Burnett-Bowie, S. A., McKay, E. A., Lee, H. & Leder, B. Z. Effects of aromatase inhibition on bone mineral density and bone turnover in older men with low testosterone levels. J. Clin. Endocrinol. Metab. 94, 4785–4792 (2009).

    Article  CAS  Google Scholar 

  4. Bagatell, C. J., Knopp, R. H., Rivier, J. E. & Bremner, W. J. Physiological levels of estradiol stimulate plasma high density lipoprotein2 cholesterol levels in normal men. J. Clin. Endocrinol. Metab. 78, 855–861 (1994).

    CAS  PubMed  Google Scholar 

  5. Ohlsson, C. et al. Comparisons of immunoassay and mass spectrometry measurements of serum estradiol levels and their influence on clinical association studies in men. J. Clin. Endocrinol. Metab. 98, E1097–E1102 (2013).

    Article  CAS  Google Scholar 

  6. Rosner, W., Hankinson, S. E., Sluss, P. M., Vesper, H. W. & Wierman, M. E. Challenges to the measurement of estradiol: an endocrine society position statement. J. Clin. Endocrinol. Metab. 98, 1376–1387 (2013).

    Article  CAS  Google Scholar 

  7. Bhasin, S. et al. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 95, 2536–2559 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, 1660 South Columbian Way (S-182-GRECC), Seattle, 98108, WA, USA

    Alvin M. Matsumoto

Authors
  1. Alvin M. Matsumoto
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alvin M. Matsumoto.

Ethics declarations

Competing interests

The author declares associations with the following companies: AbbVie (research support), Eli Lilly (consultant), Forendo, GSK (research support), GTx (consultant).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Matsumoto, A. Estrogens—not just female hormones. Nat Rev Endocrinol 9, 693–694 (2013). https://doi.org/10.1038/nrendo.2013.211

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrendo.2013.211

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing