High consumption of red meat is associated with an increased risk of type 2 diabetes mellitus, but the causality of the association is difficult to prove. Nevertheless, the findings of a large study of changes in red meat consumption add important evidence, consistent with causality of this association.
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References
Pan, A. et al. Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis. Am. J. Clin. Nutr. 94, 1088–1096 (2011).
InterAct Consortium. Association between dietary meat consumption and incident type 2 diabetes: the EPIC-InterAct study. Diabetologia 56, 47–59 (2013).
Micha, R., Wallace, S. K. & Mozaffarian, D. Red and processed meat consumption and risk of incident coronary heart disease, stroke, and diabetes mellitus: a systematic review and meta-analysis. Circulation 121, 2271–2283 (2010).
Rohrmann, S. et al. Meat consumption and mortality—results from the European Prospective Investigation into Cancer and Nutrition. BMC Med. 11, 63 (2013).
Montonen, J. et al. Consumption of red meat and whole-grain bread in relation to biomarkers of obesity, inflammation, glucose metabolism and oxidative stress. Eur. J. Nutr. 52, 337–345 (2013).
Pan, A. et al. Changes in red meat consumption and subsequent risk of type 2 diabetes mellitus: three cohorts of US men and women. JAMA Intern. Med. http://dx.doi.org/10.1001/jamainternmed.2013.6633.
Montonen, J. et al. Body iron stores and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. Diabetologia 55, 2613–2621 (2012).
Qi, L. Mendelian randomization in nutritional epidemiology. Nutr. Rev. 67, 439–450 (2009).
Simcox, J. A. & McClain, D. A. Iron and diabetes risk. Cell Metab. 17, 329–341 (2013).
Lunn, J. C. et al. The effect of haem in red and processed meat on the endogenous formation of N-nitroso compounds in the upper gastrointestinal tract. Carcinogenesis 28, 685–690 (2007).
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Joost, HG. Red meat and T2DM—the difficult path to a proof of causality. Nat Rev Endocrinol 9, 509–511 (2013). https://doi.org/10.1038/nrendo.2013.150
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DOI: https://doi.org/10.1038/nrendo.2013.150
