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Neuroendocrinology

Regulated secretory cells go to the BAR for a bud

Syndromes caused by insufficient secretion of peptide hormones originate either from an inadequate population of endocrine secretory cells or from deficiencies in the secretory process. Two remarkable new studies highlight the importance of PICK1 and ICA69 in creating the protein storage organelles needed for regulated exocytosis, independent of stimulus-secretion coupling.

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Figure 1: Two models for PICK1 and ICA69 proteins in mature secretory granules formation.

References

  1. Mironov, A. & Arvan, P. in The Golgi apparatus—state of the art 110 years after Camillo's discovery Ch. 3.11 (eds Mironov, A. & Pavelka, M.) 485–519 (Springer, Wien, 2008).

    Google Scholar 

  2. Arvan, P. & Castle, D. Sorting and storage during secretory granule biogenesis: looking backward and looking forward. Biochem. J. 332, 593–610 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Cao, M. et al. PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. PLoS Biol. 11, e1001541 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Holst, B. et al. PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance. PLoS Biol. 11, e1001542 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Gehart, H. et al. The BAR domain protein Arfaptin-1 controls secretory granule biogenesis at the trans-Golgi network. Dev. Cell 23, 756–768 (2012).

    Article  CAS  PubMed  Google Scholar 

  6. Boucrot, E. et al. Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains. Cell 149, 124–136 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Xiao, N. et al. PICK1 deficiency causes male infertility in mice by disrupting acrosome formation. J. Clin. Invest. 119, 802–812 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Meinecke, M. et al. Cooperative recruitment of dynamin and BIN/amphiphysin/Rvs (BAR) domain-containing proteins leads to GTP-dependent membrane scission. J. Biol. Chem. 288, 6651–6661 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Liu, G., Shi, Q. W. & Lu, G. X. A newly discovered mutation in PICK1 in a human with globozoospermia. Asian J. Androl. 12, 556–560 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Arvan, P., Pietropaolo, M., Ostrov, D. & Rhodes, C. J. Islet autoantigens: structure, function, localization, and regulation. Cold Spring Harb. Perspect. Med. 2, a007658 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Peter Arvan.

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Arvan, P., Castle, D. Regulated secretory cells go to the BAR for a bud. Nat Rev Endocrinol 9, 443–444 (2013). https://doi.org/10.1038/nrendo.2013.121

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