In 2012, we learned that functional thyroid tissue can be generated in vitro, and that thyroid hormones stimulate autophagy. Patients with defects in TRα have been identified, and di-iodothyropropionic acid has been shown to ameliorate MCT8 deficiency. Finally, we found that gene expression profiling can identify benign thyroid nodules.
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Acknowledgements
V. K. K. Chatterjee is supported by the Wellcome Trust (Senior Investigator) and the National Institute for Health Research Cambridge Biomedical Research Centre.
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Chatterjee, V. Advances in thyroid development, hormone action and neoplasia. Nat Rev Endocrinol 9, 74–76 (2013). https://doi.org/10.1038/nrendo.2012.253
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DOI: https://doi.org/10.1038/nrendo.2012.253
