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  • Year in Review
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Bone metabolism in 2012

Novel osteoporosis targets

Researchers are trying to develop more efficient and safer antifracture treatments. Besides the ongoing promising clinical trials involving antibodies to the Wnt antagonist sclerostin or inhibition of the osteoclast enzyme cathepsin K, the year 2012 has seen several novel osteoporosis targets identified by using different methodological approaches.

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Figure 1: Current and future antifracture treatments.

References

  1. Estrada, K. et al. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat. Genet. 44, 491–501 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Zheng, H. F. et al. WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genet. 8, e1002745 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Ralston, S. H. & Uitterlinden, A. G. Genetics of osteoporosis. Endocr. Rev. 31, 629–662 (2010).

    Article  CAS  PubMed  Google Scholar 

  4. Andrew, T., Antioniades, L., Scurrah, K. J., Macgregor, A. J. & Spector, T. D. Risk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing BMD. J. Bone Miner. Res. 20, 67–74 (2005).

    Article  PubMed  Google Scholar 

  5. Hayashi, M. et al. Osteoprotection by semaphorin 3A. Nature 485, 69–74 (2012).

    Article  CAS  PubMed  Google Scholar 

  6. Zaidi, M. & Iqbal, J. Translational medicine: Double protection for weakened bones. Nature 485, 47–48 (2012).

    Article  CAS  PubMed  Google Scholar 

  7. Sjogren, K. et al. The gut microbiota regulates bone mass in mice. J. Bone Miner. Res. 27, 1357–1367 (2012).

    Article  PubMed  Google Scholar 

  8. Ley, R. E. et al. Evolution of mammals and their gut microbes. Science 320, 1647–1651 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Cho, I. et al. Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature 488, 621–626 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Boonen, S. et al. Fracture risk and zoledronic acid therapy in men with osteoporosis. N. Engl. J. Med. 367, 1714–1723 (2012).

    Article  CAS  PubMed  Google Scholar 

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Ohlsson, C. Novel osteoporosis targets. Nat Rev Endocrinol 9, 72–74 (2013). https://doi.org/10.1038/nrendo.2012.252

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