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The coming of age of metabolic surgery

Individuals with obesity who undergo bariatric surgery are much less likely to develop type 2 diabetes mellitus than are those receiving routine care, new findings reveal. Intriguingly, baseline data on surrogate measures of insulin resistance rather than BMI were predictive of the preventive effect of surgery on type 2 diabetes mellitus.

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References

  1. Carlsson, L. M. et al. Bariatric surgery and prevention of type 2 diabetes in Swedish obese subjects. N. Engl. J. Med. 367, 695–704 (2012).

    Article  CAS  Google Scholar 

  2. Rubino, F., Schauer, P. R., Kaplan, L. M. & Cummings, D. E. Metabolic surgery to treat type 2 diabetes: clinical outcomes and mechanisms of action. Annu. Rev. Med. 61, 393–411 (2010).

    Article  CAS  Google Scholar 

  3. Adams, T. D. et al. Long-term mortality after gastric bypass surgery. N. Engl. J. Med. 357, 753–761 (2007).

    Article  CAS  Google Scholar 

  4. Dixon, J. B. et al. Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. JAMA 299, 316–323 (2008).

    CAS  Google Scholar 

  5. Mingrone, G. et al. Bariatric surgery versus conventional medical therapy for type 2 diabetes. N. Engl. J. Med. 366, 1577–1585 (2012).

    Article  CAS  Google Scholar 

  6. Schauer, P. R. et al. Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N. Engl. J. Med. 366, 1567–1576 (2012).

    Article  CAS  Google Scholar 

  7. Longitudinal Assessment of Bariatric Surgery (LABS) Consortium et al. Perioperative safety in the longitudinal assessment of bariatric surgery. N. Engl. J. Med. 361, 445–454 (2009).

  8. Rubino, R., Kaplan, L. M., Schauer, P. R. & Cummings, D. E. The Diabetes Surgery Summit consensus conference: recommendations for the evaluation and use of gastrointestinal surgery to treat type 2 diabetes mellitus. Ann. Surg. 251, 399–405 (2010).

    Article  Google Scholar 

  9. Zimmet, P., Alberti, K. G., Rubino, F. & Dixon, J. B. IDF's view of bariatric surgery in type 2 diabetes. Lancet 378, 108–110 (2011).

    Article  Google Scholar 

  10. Rubino, F. et al. Bariatric, metabolic and diabetes surgery: what's in a name? Ann. Surg. (in press).

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Correspondence to Francesco Rubino.

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Competing interests

F. Rubino declares associations with the following companies: Covidien (research grant), NGM Biopharmaceuticals (scientific advisory board). D. E. Cummings declares associations with the following companies: Johnson & Johnson (grant/research support).

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Rubino, F., Cummings, D. The coming of age of metabolic surgery. Nat Rev Endocrinol 8, 702–704 (2012). https://doi.org/10.1038/nrendo.2012.207

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