Evidence indicates that flutamide, a specific and potent androgen-receptor blocker, when given in low dose (∼1 mg/kg daily), confers a first-choice balance between antiandrogenic efficacy and hepatic safety for women and adolescent girls with hirsutism or other androgen-related symptoms.
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References
Paradisi, R. & Venturoli, S. Retrospective observational study on the effects and tolerability of flutamide in a large population of patients with various kinds of hirsutism over a 15-year period. Eur. J. Endocrinol. doi:10.1530/eje-10-0100.
Wysowski, D. K. & Fourcroy, J. L. Flutamide hepatotoxicity. J. Urol. 155, 209–212 (1996).
Martin, K. A. et al. Evaluation and treatment of hirsutism in premenopausal women: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 93, 1105–1120 (2008).
Muderris, I. I., Bayram, F. & Guven, M. Treatment of hirsutism with lowest-dose flutamide (62.5 mg/day). Gynecol. Endocrinol. 14, 38–41 (2000).
Ibáñez, L. & de Zegher, F. Flutamide-metformin therapy to reduce fat mass in hyperinsulinemic ovarian hyperandrogenism: effects in adolescents and in women on third-generation oral contraception. J. Clin. Endocrinol. Metab. 88, 4720–4724 (2003).
Calaf, J. et al. Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism. A 12-month, double-blind, parallel clinical trial. J. Clin. Endocrinol. Metab. 92, 3446–3452 (2007).
Ibáñez, L., Valls, C., Cabré, S. & de Zegher, F. Flutamide-metformin plus ethinylestradiol-drospirenone for lipolysis and antiatherogenesis in young women with ovarian hyperandrogenism: the key role of early, low-dose flutamide. J. Clin. Endocrinol. Metab. 89, 4716–4720 (2004).
Ibáñez, L. & de Zegher, F. Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in non-obese adolescents and women. Hum. Reprod. Update 12, 243–252 (2006).
Ibáñez, L. et al. Low-dose pioglitazone and low-dose flutamide added to metformin and estro-progestagens for hyperinsulinemic women with androgen excess: add-on benefits disclosed by a randomized double-placebo study over 24 months. Clin. Endocrinol. 71, 351–357 (2009).
de Zegher, F. & Ibáñez, L. Flutamide for androgen excess: low dose is best. J. Pediatr. Adolesc. Gynecol. doi:10.1016/j.jpag.2010.02.005.
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de Zegher, F., Ibáñez, L. Low-dose flutamide for hirsutism: into the limelight, at last. Nat Rev Endocrinol 6, 421–422 (2010). https://doi.org/10.1038/nrendo.2010.119
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DOI: https://doi.org/10.1038/nrendo.2010.119
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