Long-term adverse consequences of excess circulating glucocorticoids are gaining increasing recognition. The results of a study in children with endogenous Cushing syndrome now show that hypertension can persist even in remission, and raise important issues for the long-term management of these children's health, and potentially for the many children treated with glucocorticoids.
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References
Lodish, M. B. et al. Blood pressure in pediatric patients with Cushing syndrome. J. Clin. Endocrinol. Metab. 94, 2002–2008 (2009).
Colao, A. et al. Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure. J. Clin. Endocrinol. Metab. 84, 2664–2672 (1999).
Magiakou, M. A., Mastorakos, G., Zachman, K. & Chrousos, G. P. Blood pressure in children and adolescents with Cushing's syndrome before and after surgical care. J. Clin. Endocrinol. Metab. 82, 1734–1738 (1997).
Newell-Price, J., Bertagna, X., Grossman, A. B. & Nieman, L. K. Cushing's syndrome. Lancet 367, 1605–1617 (2006).
Stewart, P. M., Walker, B. R., Holder, G., O'Halloran, D. & Shackleton, C. H. 11 beta-Hydroxysteroid dehydrogenase activity in Cushing's syndrome: explaining the mineralocorticoid excess state of the ectopic adrenocorticotropin syndrome. J. Clin. Endocrinol. Metab. 80, 3617–3620 (1995).
Schäfer, S. C. et al. Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles. Am. J. Physiol. Heart Circ. Physiol. 288, H436–H444 (2005).
Koeijvoets, K. C. et al. Two common haplotypes of the glucocorticoid receptor gene are associated with increased susceptibility to cardiovascular disease in men with familial hypercholesterolemia. J. Clin. Endocrinol. Metab. 93, 4902–4908 (2008).
Newton-Cheh, C. et al. Genome-wide association study identifies eight loci associated with blood pressure. Nat. Genet. 41, 666–676 (2009).
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Newell-Price, J. Hypertension during remission of childhood Cushing syndrome. Nat Rev Endocrinol 5, 591–592 (2009). https://doi.org/10.1038/nrendo.2009.200
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DOI: https://doi.org/10.1038/nrendo.2009.200
