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Lisdexamfetamine dimesylate

Abstract

Lisdexamfetamine dimesylate (Vyvanse; New River Pharmaceuticals/Shire), a prodrug of D-amphetamine, was approved by the US FDA in February 2007 for the treatment of attention-deficit/hyperactivity disorder.

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References

  1. Elia, J. et al. Treatment of attention-deficit–hyperactivity disorder. N. Engl. J. Med. 340, 780–788 (1999).

    Article  CAS  Google Scholar 

  2. Wilens, T. E. et al. Attention deficit/hyperactivity disorder across the lifespan. Ann. Rev. Med. 53, 113–131 (2002).

    Article  CAS  Google Scholar 

  3. Kratochvil, C. J. et al. Atomoxetine: a selective noradrenaline reuptake inhibitor for the treatment of attention-deficit/hyperactivity disorder. Expert Opin. Pharmacother. 4, 1165–1174 (2003).

    Article  CAS  Google Scholar 

  4. Solanto, M. V. Dopamine dysfunction in AD/HD: integrating clinical and basic neuroscience research. Behav. Brain Res. 130, 65–71 (2002)

    Article  CAS  Google Scholar 

  5. Biederman, J. & Spencer, T. Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder. Biol. Psychiatry 46, 1234–1242 (1999).

    Article  CAS  Google Scholar 

  6. Wilens, T. E. Mechanism of action of agents used in attention-deficit/hyperactivity disorder. J. Clin. Psychiatry 67 (Suppl. 8), 32–38 (2006).

    CAS  PubMed  Google Scholar 

  7. Food and Drug Administration. FDA labelling information [online], (2007).

  8. Musser, C. J. et al. Stimulant use and the potential for abuse in Wisconsin as reported by school administrators and longitudinally followed children. J. Dev. Behav. Pediatr. 19, 187–192 (1998).

    Article  CAS  Google Scholar 

  9. Poulin, C. Medical and nonmedical stimulant use among adolescents: from sanctioned to unsanctioned use. CMAJ 165, 1039–1044 (2001).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. White, B. P. et al. Stimulant medication use, misuse, and abuse in an undergraduate and graduate student sample. J. Am. Coll. Health 54, 261–268 (2006).

    Article  Google Scholar 

  11. Teter, C. J. et al. Illicit use of specific prescription stimulants among college students: prevalence, motives, and routes of administration. Pharmacotherapy 26, 1501–1510 (2006).

    Article  Google Scholar 

  12. Babcock, Q. & Byrne, T. Student perceptions of methylphenidate abuse at a public liberal arts college. J. Am. Coll. Health 49, 143–145 (2000).

    Article  CAS  Google Scholar 

  13. Ciccone, P. E. Attempted abuse of Concerta. J. Am. Acad. Child Adolesc. Psychiatry 41,756 (2002).

  14. Stefanatos, G. A. & Baron, I. S. Attention-deficit/hyperactivity disorder: a neuropsychological perspective towards DSM-V. Neuropsychol. Rev. 17, 5–38 (2007).

    Article  Google Scholar 

  15. Fischer, M. & Barkley, R. A. Childhood stimulant treatment and risk for later substance abuse. J. Clin. Psychiatry 64, S11 19–23 (2003).

    CAS  PubMed  Google Scholar 

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Elia, J., Easley, C. & Kirkpatrick, P. Lisdexamfetamine dimesylate. Nat Rev Drug Discov 6, 343–344 (2007). https://doi.org/10.1038/nrd2315

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