Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Haematological cancer

Staging and restaging patients with lymphoma — a better approach?

Response criteria for disease assessment have important therapeutic and prognostic implications in clinical trials and in routine clinical practice. The Lugano classification has been used widely for evaluation of the response of patients with lymphoma to treatment, although the alternative Response Evaluation Criteria In Lymphoma 2017 (RECIL 2017) classification was recently proposed; these criteria are compared herein.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Younes, A. et al. International Working Group consensus response evaluation criteria in lymphoma (RECIL 2017). Ann. Oncol. http://dx.doi.org/10.1093/annonc/mdx097 (2017).

  2. Cheson, B. D. et al. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J. Clin. Oncol. 32, 3059–3068 (2014).

    Article  Google Scholar 

  3. Jerusalem, G. et al. Whole-body positron emission tomography using 18F-fluorodeoxyglucose for posttreatment evaluation in Hodgkin's disease and non-Hodgkin's lymphoma has higher diagnostic and prognostic value than classical computed tomography scan imaging. Blood 94, 429–433 (1999).

    CAS  PubMed  Google Scholar 

  4. Spaepen, K. et al. Prognostic value of positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose ([18F]FDG) after first-line chemotherapy in non-Hodgkin's lymphoma: is [18F]FDG-PET a valid alternative to conventional diagnostic methods? J. Clin. Oncol. 19, 414–419 (2001).

    Article  CAS  Google Scholar 

  5. Reinhardt, M. J., Herkel, C., Altehoefer, C., Finke, J. & Moser, E. Computed tomography and 18F-FDG positron emission tomography for therapy control of Hodgkin's and non-Hodgkin's lymphoma patients: when do we really need FDG-PET? Ann. Oncol. 16, 1524–1529 (2005).

    Article  CAS  Google Scholar 

  6. Cheson, B. D. et al. Refinement of the Lugano Classification lymphoma response criteria in the era of immunomodulatory therapy. Blood 128, 2489–2496 (2016).

    Article  CAS  Google Scholar 

  7. Hutchings, M. et al. In vivo treatment sensitivity testing with positron emission tomography/computed tomography after one cycle of chemotherapy for Hodgkin lymphoma. J. Clin. Oncol. 32, 2705–2711 (2014).

    Article  Google Scholar 

  8. Johnson, P. et al. Adapted treatment guided by interim PET-CT scan in advanced Hodgkin's lymphoma. N. Engl. J. Med. 374, 2419–2429 (2016).

    Article  Google Scholar 

  9. Dabaja, B. S. et al. Clinical implications of positron emission tomography-negative residual computed tomography masses after chemotherapy for diffuse large B-cell lymphoma. Leuk. Lymphoma 54, 2631–2638 (2013).

    Article  CAS  Google Scholar 

  10. Roschewski, M. et al. Dynamic monitoring of circulating tumor DNA in non-Hodgkin lymphoma. Blood 127, 3127–3132 (2016).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The work of V.R.B. is supported by the 2016–2017 Physician–Scientist Training Program Grant from the College of Medicine, University of Nebraska Medical Center, USA.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to James O. Armitage.

Ethics declarations

Competing interests

J.O.A is a consultant for Conatus (independent data monitoring committee) and Samus Therapeutics, and is a member of the board of directors for Tesaro. V.R.B. declares no competing interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bhatt, V., Armitage, J. Staging and restaging patients with lymphoma — a better approach?. Nat Rev Clin Oncol 14, 527–528 (2017). https://doi.org/10.1038/nrclinonc.2017.81

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrclinonc.2017.81

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer