Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Lung cancer

Best supportive care — a reasonable option for patients with brain metastases?

Most patients with cancer who develop brain metastases have a very poor prognosis, especially those with brain metastases from non-small-cell lung cancer. The short life-expectancy of these patients, which is typically measured in weeks or a few months, raises an important question: do they benefit from whole-brain radiotherapy, or are they appropriately treated with best supportive care alone? A recent randomized trial sought to answer this question.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Rades, D. et al. Two radiation regimens and prognostic factors for brain metastases in non-small cell lung cancer patients. Cancer 110, 1077–1082 (2007).

    Article  Google Scholar 

  2. Mulvenna, P. et al. Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ): results from a phase 3, non-inferiority, randomised trial. Lancet http://dx.doi.org/10.1016/S0140-6736(16)30825-X (2016).

  3. Sperduto, P. W. et al. Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients. Int. J. Radiat. Oncol. Biol. Phys. 77, 655–661 (2010).

    Article  Google Scholar 

  4. Rades, D. et al. A new survival score for patients with brain metastases from non-small cell lung cancer. Strahlenther. Onkol. 189, 777–781 (2013).

    Article  CAS  Google Scholar 

  5. Gerdan, L. et al. Brain metastasis from non-small cell lung cancer (NSCLC): prognostic importance of the number of involved extracranial organs. Strahlenther. Onkol. 190, 64–67 (2014).

    Article  CAS  Google Scholar 

  6. Rades, D. et al. A new survival score for patients with brain metastases who received whole-brain radiotherapy (WBRT) alone. Radiother. Oncol. 108, 123–127 (2013).

    Article  Google Scholar 

  7. Wong, J. et al. Symptoms and quality of life in cancer patients with brain metastases following palliative radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 75, 1125–1131 (2009).

    Article  Google Scholar 

  8. Komosinska, K. et al. Prospective evaluation of the palliative effect of whole-brain radiotherapy in patients with brain metastases and poor performance status. Acta Oncol. 49, 382–388 (2010).

    Article  Google Scholar 

  9. Rades, D. et al. Dose-escalation of whole-brain radiotherapy for brain metastasis in patients with a favorable survival prognosis. Cancer 118, 3853–3859 (2012).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Dirk Rades.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rades, D., Schild, S. Best supportive care — a reasonable option for patients with brain metastases?. Nat Rev Clin Oncol 13, 722–724 (2016). https://doi.org/10.1038/nrclinonc.2016.179

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrclinonc.2016.179

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer