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Haematological cancer

Idelalisib—targeting PI3Kδ in patients with B-cell malignancies

Nature Reviews Clinical Oncology volume 11, pages 184–186 (2014)Cite this article

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Idelalisib, the first PI3Kδ inhibitor in clinical use, has excellent activity in patients with chronic lymphocytic leukaemia and indolent B-cell lymphomas, heralding a new era of targeted therapy for these types of cancer. Idelalisib intercepts critical communications between B cells and the microenvironment, including B-cell receptor signalling and chemokine networks.

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Figure 1: Effects of idelalisib on crosstalk between malignant B cells and the microenvironment.

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Acknowledgements

The study was supported by a Cancer Prevention and Research Institute of Texas (CPRIT) grant (to J.A.B.), and a Leukemia & Lymphoma Society Scholar Award in Clinical Research (to J.A.B.).

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Authors and Affiliations

  1. Department of Leukemia, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, 77030, TX, USA

    Jan A. Burger

  2. Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, CB22 3AT, UK

    Klaus Okkenhaug

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  1. Jan A. Burger
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  2. Klaus Okkenhaug
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Correspondence to Jan A. Burger.

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Competing interests

J.A.B. received research funding from Gilead and Pharmacyclics. K.O. declares no competing interests.

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Burger, J., Okkenhaug, K. Idelalisib—targeting PI3Kδ in patients with B-cell malignancies. Nat Rev Clin Oncol 11, 184–186 (2014). https://doi.org/10.1038/nrclinonc.2014.42

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