Healthy individuals carrying the t(14;18) translocation might never develop follicular lymphoma (FL). However, individuals with more than 1 in 10,000 cells carrying this translocation are at high-risk of developing FL. The identification of this high-risk population will help define the pathways driving FL and designing targeted therapies to use before its development.
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Sarkozy, C., Coiffier, B. The translocation behind follicular lymphoma development. Nat Rev Clin Oncol 11, 444–445 (2014). https://doi.org/10.1038/nrclinonc.2014.100
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DOI: https://doi.org/10.1038/nrclinonc.2014.100