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Chemotherapy

Adjuvant chemotherapy in older patients with breast cancer

Nature Reviews Clinical Oncology volume 6, pages 563–565 (2009)Cite this article

A prospective, randomized trial has shown that standard adjuvant chemotherapy is superior to capecitabine in the treatment of women with breast cancer aged 65 years or older; on the basis of the results of this study, capecitabine cannot be recommended in this setting.

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References

  1. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Adjuvant chemotherapy in oestrogen-receptor-poor breast cancer: patient-level meta-analysis of randomised trials. Lancet 371, 29–40 (2008).

  2. Giordano, S. H., Duan, Z., Kuo, Y. F., Hortobagyi, G. N. & Goodwin, J. S. Use and outcomes of adjuvant chemotherapy in older women with breast cancer. J. Clin. Oncol. 24, 2750–2756 (2006).

    Article  PubMed Central  Google Scholar 

  3. Elkin, E. B., Hurria, A., Mitra, N., Schrag, D. & Panageas, K. S. Adjuvant chemotherapy and survival in older women with hormone receptor-negative breast cancer: assessing outcome in a population-based, observational cohort. J. Clin. Oncol. 24, 2757–2764 (2006).

    Article  PubMed Central  Google Scholar 

  4. Tai, P. et al. Modeling the effect of age in T1–2 breast cancer using the SEER database. BMC Cancer 5, 130–139 (2005).

    Article  PubMed Central  Google Scholar 

  5. Daidone, M. G., Coradini, D., Martelli, G. & Veneroni, S. Primary breast cancer in elderly women: biological profile and relation with clinical outcome. Crit. Rev. Oncol. Hematol. 45, 313–325 (2003).

    Article  PubMed Central  Google Scholar 

  6. Muss, H. B. et al. Adjuvant chemotherapy in older women with early-stage breast cancer. N. Engl. J. Med. 360, 2055–2065 (2009).

    Article  CAS  PubMed Central  Google Scholar 

  7. Partridge, A. H., Wang, P. S., Winer, E. P. & Avorn, J. Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer. J. Clin. Oncol. 21, 602–606 (2003).

    Article  CAS  PubMed Central  Google Scholar 

  8. Crivellari, D. et al. Burdens and benefits of adjuvant cyclophosphamide, methotrexate, and fluorouracil and tamoxifen for elderly patients with breast cancer: the International Breast Cancer Study Group Trial VII. J. Clin. Oncol. 18, 1412–1422 (2000).

    Article  CAS  PubMed Central  Google Scholar 

  9. Jones, S. et al. Docetaxel with cyclophosphamide is associated with an overall survival benefit compared with doxorubicin and cyclophosphamide: 7-Year follow-up of US Oncology Research Trial. J. Clin. Oncol. 27, 1177–1183 (2009).

    Article  CAS  PubMed Central  Google Scholar 

  10. Wang, Y. et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet 365, 671–679 (2005).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands

    Agnes Jager, Jaap Verweij & Stefan Sleijfer

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  1. Agnes Jager
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  2. Jaap Verweij
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  3. Stefan Sleijfer
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Correspondence to Jaap Verweij.

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The authors declare no competing financial interests.

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Jager, A., Verweij, J. & Sleijfer, S. Adjuvant chemotherapy in older patients with breast cancer. Nat Rev Clin Oncol 6, 563–565 (2009). https://doi.org/10.1038/nrclinonc.2009.142

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  • DOI: https://doi.org/10.1038/nrclinonc.2009.142

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