Cardiac rhythm disorders, or 'arrhythmias', are major sources of morbidity and mortality, and have been challenging to treat because classic pharmacological therapies are often ineffective and sometimes dangerous. In the past decade, groundbreaking developments have revolutionized the management of arrhythmias and prepared the groundwork for new advances in the future.
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References
Bardy, G. H. et al. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N. Engl. J. Med. 352, 225–237 (2005).
Haïssaguerre, M. et al. Sudden cardiac arrest associated with early repolarization. N. Engl. J. Med. 358, 2016–2023 (2008).
Itzhaki, I. et al. Modelling the long QT syndrome with induced pluripotent stem cells. Nature 471, 225–229 (2011).
Roy, D. et al. Rhythm control versus rate control for atrial fibrillation and heart failure N. Engl. J. Med. 358, 2667–2677 (2008).
Van Gelder, I. C. et al. Lenient versus strict rate control in patients with atrial fibrillation. N. Engl. J. Med. 362, 1363–1373 (2010).
Connolly, S. J. et al. Dronedarone in high-risk permanent atrial fibrillation. N. Engl. J. Med. 365, 2268–2276 (2011).
Cosedis Nielsen, J. et al. Radiofrequency ablation as initial therapy in paroxysmal atrial fibrillation. N. Engl. J. Med. 367, 1587–1595 (2012).
Narayan, S. M. et al. Treatment of atrial fibrillation by the ablation of localized sources: CONFIRM (Conventional Ablation for Atrial Fibrillation With or Without Focal Impulse and Rotor Modulation) trial. J. Am. Coll. Cardiol. 60, 628–636 (2012).
Connolly, S. J. et al. Dabigatran versus warfarin in patients with atrial fibrillation. N. Engl. J. Med. 361, 1139–1151 (2009).
Abed, H. S. et al. Effect of weight reduction and cardiometabolic risk factor management on symptom burden and severity in patients with atrial fibrillation: a randomized clinical trial. JAMA 310, 2050–2060 (2013).
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S.N. is funded by the Canadian Institutes of Health Research (6957 and 44365) and the Heart and Stroke Foundation of Canada.
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Nattel, S. Cardiac fibrillation—challenges and evolving solutions. Nat Rev Cardiol 11, 626–627 (2014). https://doi.org/10.1038/nrcardio.2014.133
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DOI: https://doi.org/10.1038/nrcardio.2014.133