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Biomarkers

Pros and cons of high-sensitivity assays for cardiac troponin

Nature Reviews Cardiology volume 9, pages 616–618 (2012)Cite this article

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A 3-h algorithm using high-sensitivity assays for cardiac troponin to rule out myocardial infarction (MI) is recommended in current ESC guidelines. Whether faster rule-out algorithms can discriminate between MI and other conditions that elevate the troponin level, or be safely implemented across the whole spectrum of patient risk, is unclear.

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Figure 1: Effects of high-sensitivity assays for cardiac muscle troponin (cTn) on clinical sensitivity and specificity.

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  1. Department of Internal Medicine III, Cardiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany

    Evangelos Giannitsis & Hugo A. Katus

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  1. Evangelos Giannitsis
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  2. Hugo A. Katus
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Correspondence to Evangelos Giannitsis.

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Competing interests

E. Giannitsis is or has been a member of the speakers' bureau of BRAHMS Thermo Fisher. Additionally, he is or has been a consultant for, a member of the speakers' bureau of, and received grant or research support from, Roche Diagnostics. H. A. Katus is or has been a consultant for, a member of the speakers' bureau of, and a patent holder or applicant with, Roche Diagnostics.

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Giannitsis, E., Katus, H. Pros and cons of high-sensitivity assays for cardiac troponin. Nat Rev Cardiol 9, 616–618 (2012). https://doi.org/10.1038/nrcardio.2012.142

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