Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Prevention

Reducing the risk of CVD in patients with periodontitis

Nature Reviews Cardiology volume 7, pages 479–480 (2010)Cite this article

Subjects

The association between periodontitis and other chronic diseases, such as cardiovascular disease (CVD) and type 2 diabetes mellitus, could be related to systemic inflammation initiated by a local inflammatory challenge. Oliveira et al. have added lack of oral hygiene, and its link with systemic inflammation, to the spectrum of risk factors for CVD.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Link between periodontitis and cardiovascular disease.

References

  1. de Oliveira, C., Watt, R. & Hamer, M. Toothbrushing, inflammation, and risk of cardiovascular disease: results from Scottish Health Survey. BMJ 340, c2451 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Wu, T. et al. Periodontal disease and risk of cerebrovascular disease: the First National Health and Nutrition Examination Survey and its follow-up study. Arch. Intern. Med. 160, 2749–2755 (2000).

    Article  CAS  PubMed  Google Scholar 

  3. Bahekar, A. A., Singh, S., Saha, S., Molnar, J. & Arora, R. The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis. Am. Heart J. 154, 830–837 (2007).

    Article  PubMed  Google Scholar 

  4. Humphrey, L. L., Fu, R., Buckley, D. I., Freeman, M. & Helfand, M. Periodontal disease and coronary heart disease incidence: a systematic review and meta-analysis. J. Gen. Intern. Med. 23, 2079–2086 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Chen, Y. W. et al. Periodontitis may increase the risk of peripheral arterial disease. Eur. J. Vasc. Endovasc. Surg. 35, 153–158 (2008).

    Article  CAS  PubMed  Google Scholar 

  6. Friedewald, V. E. et al. The American Journal of Cardiology and Journal of Periodontology editors' consensus: periodontitis and atherosclerotic cardiovascular disease. J. Periodontol. 80, 1021–1032 (2009).

    Article  PubMed  Google Scholar 

  7. Paraskevas, S., Huizinga, J. D. & Loos, B. G. A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J. Clin. Periodontol. 35, 277–290 (2008).

    Article  CAS  PubMed  Google Scholar 

  8. Offenbacher, S. et al. Results from the Periodontitis and Vascular Events (PAVE) Study: a pilot multicentered, randomized, controlled trial to study effects of periodontal therapy in a secondary prevention model of cardiovascular disease. J. Periodontol. 80, 190–201 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Haraszthy, V. I., Zambon, J. J., Trevisan, M., Zeid, M. & Genco, R. J. Identification of periodontal pathogens in atheromatous plaques. J. Periodontol. 71, 1554–1560 (2000).

    Article  CAS  PubMed  Google Scholar 

  10. Jain, A., Batista, E., Serhan, C., Stahl, G. L. & Van Dyke, T. E. Role for periodontitis in the progression of lipid deposition in an animal model. Infect. Immun. 71, 6012–6018 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Oral Biology, State University of New York at Buffalo, Baird Research Park, 1576 Sweet Home Road, Suite 103, Amherst, 14228, NY, USA

    Robert J. Genco

  2. Department of Periodontology and Oral Biology, Clinical Research Center, Boston University Goldman School of Dental Medicine, 100 E. Newton Street, G-107, Boston, 02118, MA, USA

    Thomas E. Van Dyke

Authors
  1. Robert J. Genco
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thomas E. Van Dyke
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Robert J. Genco.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Genco, R., Van Dyke, T. Reducing the risk of CVD in patients with periodontitis. Nat Rev Cardiol 7, 479–480 (2010). https://doi.org/10.1038/nrcardio.2010.120

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrcardio.2010.120

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing