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Histone methyltransferases, diet nutrients and tumour suppressors

Nature Reviews Cancer volume 2, pages 469–476 (2002)Cite this article

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Abstract

It is well known that an insufficiency of dietary methyl-group donors can cause cancer, and that a deficiency in methylation is characteristic of cancer, but how carcinogenesis results from abnormal methyl-donor metabolism has long remained a matter of speculation. Recently, however, it has been found that some histone methyltransferases, which require methyl donors for activity, are tumour suppressors.

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Figure 1: Comparison of the SET and PR domains with a plant protein lysine methyltransferase.
Figure 2: The yin–yang of PR- and SET-domain genes in carcinogenesis.
Figure 3: The methionine metabolism pathway.

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  • 17 May 2002

    There was an error in the third paragraph, fourth sentance: this originally read "More recently, it was realized that they belong to a protein superfamily that contains one of two similar... "They belong to" and "that" were removed and the sentance re-written by request of the author. This incorrect version appeared as CP onlin material for c. one week.

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  1. There was an error in the third paragraph of the advanced online publication of this article. The error has now been corrected in the HTML and PDF versions, and the article is correct in the print issue.

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Author information

Authors and Affiliations

  1. the Cancer Research Center, Program in Oncogenes and Tumor Suppressor Genes, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, 92037, California, USA

    Shi Huang

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  1. Shi Huang
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DATABASES

Cancer.gov

breast cancer

cervical cancer

colon cancer

liver cancer

lung cancer

melanoma

myeloid leukaemia

neuroblastoma

osteosarcoma

LocusLink

Apc

BOP

BRCA1

BRCA2

CDKN2A

E2F1

EVI1

H3

MDS1

MTAP

MTHFR

MYC

NSD1

NSD2

p53

PRDI-BF1

PRDM16

protein kinase C

RB

Riz1

RIZ1

RIZ2

spermidine synthase

SUV39H1

SUV39H2

Trp53

uracil DNA glycosylase

OMIM

Sotos syndrome

<i>Saccharomyces</i> Genome Database

Mec3

Set1

FURTHER INFORMATION

Pfam Database

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Huang, S. Histone methyltransferases, diet nutrients and tumour suppressors. Nat Rev Cancer 2, 469–476 (2002). https://doi.org/10.1038/nrc819

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